.Set-AdvancedSetting can be used to set it.

Get-AdvancedSetting -Entity (Get-Cluster -Name Cluster) -Name SettingName | Set-AdvancedSetting -Value NewValue

Set-VmHostAdvancedConfiguration

Obsolete:

references:

Set-AdvancedSetting Command | Vmware PowerCLI Reference (broadcom.com)