.Set-AdvancedSetting can be used to set it.

Get-AdvancedSetting -Entity (Get-Cluster -Name Cluster) -Name SettingName | Set-AdvancedSetting -Value NewValue

Set-VmHostAdvancedConfiguration

Obsolete:

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references:

Set-AdvancedSetting Command | Vmware PowerCLI Reference (broadcom.com)